1085 ASTHMA AND GASTROESOPHAGEAL REFLUX: FUNDOPLICATION DECREASES NEED FOR SYSTEMIC CORTICOSTEROIDS. Hadar Spivak, C. Daniel Smith, Alounthith Phichith, Kathy Galloway, Patrick J. Waring, John G. Hunter Department of Surgery and Medicine, Emory University School of Medicine, Atlanta, Georgia.

3355 AMMONIA INHIBITS REGULATED CHLORIDE SECRETION IN IN VITRO HUMAN COLON. TC O'Brien, M Riegler*, EC Mun, M Prasad, C Pothoulakis*, JB Matthews. Department. of Surgery and *Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA.

3636 ATTENUATED HSV-1 KILLS HUMAN PANCREATIC CANCER CELLS IN VITRO. J.H. Lee1, H.J. Federoff2, J.L. Peacock1, and L.O. Schoeniger1. Departments of Surgery1 and Neurology2, University of Rochester Medical Center, Rochester, NY.

4472 HER2/NEU OVEREXPRESSION INTERFERES WITH RETINO-BLASTOMA PROTEIN-MEDIATED CELL CYCLE REGULATION IN HUMAN PANCREATIC CARCINOMA CELLS. H. Roh, J. Pippen and J.A. Drebin, Department of Surgery, Washington University School of Medicine, St. Louis, MO.

4479 THE ROLE OF THE LOWER ESOPHAGEAL SPHINCTER AND HIATAL HERNIA IN THE PATHOGENESIS OF GASTRO-ESOPHAGEAL REFLUX DISEASE. M. Fein, M.P. Ritter, T.R. DeMeester, J.H. Peters, S. Öberg, J.A. Hagen, C.G. Bremner. Univ. of Southern California, Dept. of Surgery, Los Angeles, CA.

1295 SELECTIVE DECREASES IN LEVELS OF mRNA ENCODING A WATER CHANNEL (AQP3) IN ILEAL MUCOSA AFTER ILEOSTOMY. J. Purdy, R.R. Cima, M. A. Doble, M.J. Zinner, and D.I. Soybel. Dept. of Surgery, Brigham and Women's Hospital and West Roxbury V.A.M.C., Boston, MA.

2705 GLUTAMINE PREVENTS LPS-INDUCED NF-_B ACTIVATION IN HUMAN INTESTINAL EPITHELIAL CELLS. MR Moon, TA Pritts, AL Salzman, JE Fischer, and PO Hasselgren. Department of Surgery, University of Cincinnati Medical Center, Children's Hospital Medical Center, and Shriners Burn Institute. Cincinnati, Ohio.

3755 LAPAROSCOPIC FUNDOPLICATION IN PATIENTS WITH BARRETT'S ESOPHAGUS. S. Öberg, J.H Peters, T.R DeMeester, M.P. Ritter, P.A. Crookes, S.R. DeMeester, J.A. Hagen, C.G. Bremner. Department of Surgery, University of Southern California, Los Angeles, California.

1063 THE ENTEROTROPHIC EFFECTS OF GLUCAGON-LIKE PEPTIDE 2 ARE ENHANCED BY NEUROTENSIN. D.A. Litvak, M.R. Hellmich, B.M. Evers, C.M. Townsend, Jr., Department of Surgery, The University of Texas Medical Branch. Galveston, Texas.

1064 CYCLIN D3 IS ESSENTIAL FOR INTESTINAL EPITHELIAL CELL PROLIFERATION. T.C. Ko, F. Pan, D.B. Brown, E.A. Thompson, R.D. Beauchamp*. Department of Surgery, The University of Texas Medical Branch, Galveston, TX and *Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN.

1065 EXTRACELLULAR MATRIX MODULATES ENTEROCYTE GROWTH VIA DOWN REGULATION OF c-jun BUT IS INDEPENDENT OF p21 AND p27 EXPRESSION. S.I. Wolpert, K.M. Lally, J. Li J-Y Wang, B.L. Bass. The Department of Surgery, The University of Maryland and the Baltimore VAMC; Baltimore, MD.

1066 LOSS OF MATRIX-DEPENDENT CYTOSKELETAL TYROSINE KINASE SIGNALS MAY REGULATE INTESTINAL EPITHELIAL DIFFERENTIA-TION DURING MUCOSAL HEALING. Y.-W. Liu, M.A. Sanders, M.D. Basson. Depts. of Surgery, Yale University, New Haven, CT and CT VA Health Care System, West Haven, CT.

1067 A POSSIBLE ROLE FOR p21 IN ALTERATION OF THE ENTEROCYTE DIFFERENTIATION ASSOCIATED WITH PREMATURE CELL CYCLE WITHDRAWAL. S. Archer, S. Meng, R.A. Hodin. Dept. of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

1068 EFFECT OF NUTRITIONAL ROUTE ON COLONIC ANASTOMOTIC HEALING IN THE RAT. T. Kiyama, D. T. Efron, U. Tantry, A. Barbul. Dept Surgery, Sinai Hospital & The Johns Hopkins Medical Institutions, Baltimore, MD.

1069 CALCIUM ACCENTUATES GASTRIC INJURY INDUCED BY ETHANOL. E.R. Kokoska, G.S. Smith, T.A.Miller, Saint Louis University Health Sciences Center. St. Louis, MO.

1070 INVOLVEMENT OF FAS IN TAMOXIFEN-INDUCED APOPTOSIS OF CHOLANGIOCARCINOMA. A. Pickens, G. Pan, J. McDonald and S.M. Vickers. The University of Alabama at Birmingham School of Medicine, Birmingham, AL.

1071 HUMAN PERIAMPULLARY CARCINOMAS EXPRESS CHOLECYSTO-KININ (CCK-A) RECEPTORS. R.A. Moonka, W. Zhou, and R.H. Bell, Jr. Department of Surgery, University of Washington School of Medicine and VA Medical Center, Seattle, WA.

1072 GROWTH FACTOR RECEPTOR ANTAGONISM RESULTS IN ENHANCED RESPONSE TO CHEMORADIATION THERAPY IN COLON CANCER CELLS. A Shurin, E Perer, Y Pang, K Romaguera*, E Zakris*, DJ Beech. Tulane University School of Medicine, Department of Surgery, Section of Radiation Oncology*, New Orleans, LA.

1073 INFLUENCE OF P53 STATUS ON THE EFFICACY OF HSV-MEDIATED CANCER GENE THERAPY. S.S. Yoon, N.M. Carroll, E.A. Chiocca, K.K. Tanabe. Dept. of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

1074 THERAPY OF MICROCIRCULATORY DISORDERS IN SEVERE ACUTE PANCREATITIS: WHAT IS MORE EFFECTIVE: PLATELET ACTIVATING FACTOR- OR ENDOTHELIN-RECEPTOR BLOCKADE? Th. Foitzik, H.G. Hotz, B. Hotz, G. Eibl, M. Kirchengast*, H.J. Buhr. Dept. of Surgery, Benjamin Franklin Medical Center, Freie Universitåt Berlin and *Knoll AG, Ludwigshafen, Germany.

1075 CHARACTERIZATION AND REDUCTION OF ISCHEMIA/ REPERFUSION-INJURY AFTER EXPERIMENTAL PANCREAS TRANSPLANTATION. H. Mayer, J. Schmidt, J. Thies, E. Ryschich, M.M. Gebhard*, Ch. Herfarth, E. Klar; Department of Surgery and *Department of Experimental Surgery, University of Heidelberg, Germany.

1076 PREVENTION OF ENDOTOXIN-INDUCED MORTALITY IS ASSOC-IATED WITH BLOCKADE OF BOTH PGE2 SYNTHESIS AND CALCIUM FLUX IN KUPFFER CELLS. CR Roland, B Naziruddin, Y Nakafusa, T Mohanakumar, MW Flye, Washington University School of Medicine. St. Louis, MO.

2317 MOLECULAR GENETICS OF PANCREATIC CANCER. RJ Bold, DB Evans, KR Hess, AM Grau, F Sinicrope, KR Cleary, PJ Chiao, JL Abbruzzese, The University of Texas M. D. Anderson Cancer Center, Houston, TX.

2318 STAGING LAPAROSCOPY FOR PANCREATIC CANCER SHOULD BE USED TO SELECT THE BEST PALLIATION, NOT TO INCREASE RESECTION RATE. E Luque-de León, GG Tsiotos, BM Balsiger, J Barnwell, L Burgart, MG Sarr. Dept of Surg, Mayo Clinic, Rochester, MN.

2319 MAJOR VASCULAR RESECTION AS PART OF PANCREATICO-DUODENECTOMY FOR CANCER: CLINICAL, RADIOLOGIC AND PATHOLOGIC ANALYSIS. RJ Bold, C Charnsangavej, KR Cleary, JE Lee, PWT Pisters, DB Evans. The University of Texas M.D. Anderson Cancer Center, Houston, TX.

2320 EARLY FAILURE OF INTESTINAL BARRIER FUNCTION AND ENDOTOXEMIA IN SEVERE ACUTE PANCREATITIS. BJ Ammori, PG Leeder, RFG King, *GR Barclay, IG Martin, M Larvin, MJ McMahon. University of Leeds Academic Surgical Unit, The General Infirmary, Leeds UK, and *Blood Transfusion Service, Royal Infirmary, Edinburgh, UK.

2321 LAPAROSCOPIC ROUX-EN-Y GASTRIC BYPASS: INITIAL RESULTS. P.R. Schauer S. Ikramuddin, W. Gourash. Department of Surgery, University of Pittsburgh, Pittsburgh, PA. USA.

2322 MALABSORPTIVE PROCEDURES FOR SEVERE OBESITY: COMPARISON OF PANCREATICOBILIARY BYPASS (PBB) AND VERY, VERY LONG ROUX-EN-Y GASTRIC BYPASS (VVLGB). MM Murr, BM Balsiger, FP Kennedy, MG Sarr. Dept. of Surgery, Mayo Clinic, Rochester, MN.

2323 LAPAROSCOPIC CHOLECYSTECTOMY AS A "TRUE" OUTPATIENT PROCEDURE: INITIAL EXPERIENCE IN 100 CONSECUTIVE PATIENTS. KD Lillemoe, JM Hardacre, MA Talamini, CJ Yeo, DS Snyder, SD Parker. Depts of Surgery and Anesthesiology, The Johns Hopkins Medical Institutions, Baltimore, MD.

2324 EVALUATION OF LAPAROSCOPIC CHOLECYSTECTOMY IN PATIENTS WITH HEPATIC CIRRHOSIS: A FIVE YEAR EXPERIENCE. C. Friel, J. Stack, R.A. Forse, T. Babineau Department of Surgery. Beth Israel Deaconess Hospital. Harvard Medical School. Boston, MA.

2325 DIAGNOSIS AND MANAGEMENT OF CHOLANGIOCARCINOMA IN PRIMARY SCLEROSING CHOLANGITIS. S.A.Ahrendt, H.A.Pitt, A.Nakeeb, A.S.Klein, K.D.Lillemoe, A.N.Kalloo, and J.L.Cameron. Depts. of Surgery and Medicine, The Johns Hopkins University, Baltimore, MD and Dept. of Surgery, Medical College of Wisconsin, Milwaukee, WI.

2326 IMPROVED FUNCTIONAL OUTCOME AFTER LAPAROSCOPIC FUNDOPLICATION BY COMPLETE GASTRIC FUNDUS MOBILIZATION. Jan Dalenbäck, Hans Lönroth, Anne Blomqvist, Lars Lundell. Department of Surgery, Sahlgrenska University Hospital, University of Gothenburg, SWEDEN.

2327 MULTIVARIATE ANALYSIS OF THE FACTORS PREDICTING OUTCOME AFTER LAPAROSCOPIC NISSEN FUNDOPLICATION. G.M.R. Campos, J.H. Peters, T.R. DeMeester, S. Öberg, M. DeVos-Shoop, J. Theisen, M. Hashemi, P. Crookes, J. Hagen, C.G. Bremner. Department of Surgery, University of Southern California, Los Angeles, CA.

2328 LAPAROSCOPIC TOUPET IS AN INADEQUATE PROCEDURE FOR PATIENTS WITH SEVERE REFLUX DISEASE. K.D. Horvath, B.A. Jobe, L.L. Swanstrom, Oregon Health Sciences University and Legacy Health Systems, Portland, OR.

2329 BARRETT'S ESOPHAGUS: A SURGICAL DISEASE. M.G. Patti, C.V. Feo, M. Arcerito, S. Worth, M. De Pinto, J. Tong, V.C. Gibbs, M. Ahmadi, W. Gantert, D. Tyrrell, L.D. Ferrell, and L.W. Way, Department of Surgery, University of California, San Francisco. San Francisco, California.

2330 ENDOSCOPIC LASER ABLATION OF BARRETT'S MUCOSA FOLLOWED BY NISSEN FUNDOPLICATION: RESULTS OF A PILOT STUDY. A.Carazzone,L.Bonavina, A.Segalin, L.Antoniazzi, C.Ceriani, A.Peracchia. Dept. of General and Oncologic Surgery Milan, Italy.

2331 VARIABILITY IN THE COMPOSITION OF PHYSIOLOGIC DUODENO-GASTRIC REFLUX. K.-H. Fuchs, J. Maroske, M. Fein, H. Tigges, M.P. Ritter, J. Heimbucher, A. Thiede. Department of Surgery, University of Würzburg, Germany.

2332 IMPLEMENTATION OF A CLINICAL PATHWAY DECREASES LENGTH OF STAY AND COST FOR BOWEL RESECTION. TA Pritts, MS Nussbaum, LV Flesch, EJ Fegelman, AJ Parikh, and JE Fischer. Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio.

2332 IMPLEMENTATION OF A CLINICAL PATHWAY DECREASES LENGTH OF STAY AND COST FOR BOWEL RESECTION. TA Pritts, MS Nussbaum, LV Flesch, EJ Fegelman, AJ Parikh, and JE Fischer. Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio.

2333 THE CUMULATIVE RISK OF DEVELOPING POLYPS OR MALIGNANCY AT THE ILEO-POUCH-ANAL ANASTO-MOSIS IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS (FAP). P. van Duijvendijk1, J.F.M. Slors1, C.W. Taat1, S. Bülow2, L. Bertario3, J.H.C. Kuijpers4, W.R. Schouten5, J.G. Guillem6 H.F.A. Vasen7, Dept. of Surgery, Academic Medical Centre Amsterdam1, Danish Polyposis Registry2, Italian Registry of Familial Polyposis3, Dept. of Surgery, University Hospital Nijmegen4, Dept. of Surgery, University Hospital Rotterdam5, Memorial Sloan-Kettering Cancer Center, New York6, The Netherlands Foundation for the Detection of Hereditary Tumours7.

2334 ILEAL POUCH SALVAGE FOLLOWING FAILED ILEAL POUCH-ANAL ANASTOMOSIS. S. Saltzberg, C. DiEdwardo, T. Scott, and W. LaMorte, J. M. Becker, Department of Surgery, Boston University School of Medicine, Boston, MA.

2335 HOSPITAL PROCEDURE VOLUME AND HOSPITAL TEACHING STATUS DO NOT INFLUENCE OPERATIVE MORTALITY OR LONG-TERM SURVIVAL FOR RECTAL CANCER IN A LARGE GENERAL POPULATION: AN OUTCOMES STUDY. M.Simunovic, E. Sigurdson, T.To, N.Baxter, A.Balshem, Z.Cohen, R.McLeod and E.Ross. Institute for Clinical Evaluative Sciences, Toronto, Ontario. Fox Chase Cancer Center, Philadelphia, PA.

2336 B2 RECTAL CANCER: IS RADIATION THERAPY FOR LOCAL CONTROL NECESSARY? N.B. Merchant, J.G. Guillem, P.B. Paty, W.E. Enker, A.M. Cohen, Memorial Sloan-Kettering Cancer Center, New York, NY.

2337 EFFICACY OF COMBINED CHEMO-RADIATION THERAPY FOR EPIDERMOID CARCINOMA OF THE ANAL CANAL FOR TUMORS LARGER THAN 5 CENTIMETERS. Peter S. Paik. Larry Leichman, Oscar Streeter Jr., Robert W. Beart Jr. Division of Colorectal Surgery, University of Southern California Medical Center, Los Angeles, California.

3582 NEAR TOTAL GASTRECTOMY FOR SEVERE POSTVAGOTOMY GASTROPARESIS: CRITICAL ANALYSIS OF EARLY AND LATE LONG-TERM RESULTS AT A TERTIARY CENTER. AW Forstner-Barthell, MM Murr, S Nitecki, KA Kelly, M Camilleri, CM Prather, MG Sarr. Depts of Surgery and Internal Medicine, Mayo Clinic, Rochester, MN.

3583 ROLE OF ANGIOGRAPHY AND EMBOLIZATION FOR ACUTE MASSIVE UPPER GASTROINTESTINAL HEMORRHAGE. R. M. Walsh, P. Anain, M. Geisinger, D. Vogt, J. Mayes, S. Grundfest-Broniatowski and J.M. Henderson. Department of General Surgery and Radiology, Cleveland Clinic Foundation, Cleveland, Ohio.

3584 EFFECT OF MICROSCOPIC RESECTION LINE DISEASE ON GASTRIC CANCER SURVIVAL. S.H. Kim, M.S. Karpeh, D.S. Klimstra, D. Leung, and M.F. Brennan, Memorial Sloan-Kettering Cancer Center. New York, NY.

3585 PRE-OPERATIVE SUPERSELECTIVE INTRA-ARTERIAL CHEMO-THERAPY FOR THE TREATMENT OF UNRESECTABLE GASTRIC CARCINOMA. Igor B. Shchepotin1,2, Vyatcheslav Chorny2, Ludmila Gooluck2, Stephen R.T. Evans1. 1Department of Surgery, George Washington University, Washington ,D.C., 20037, 2Ukrainian Institute of Oncology and Radiology, Kiev, Ukraine.

3586 APPENDECTOMY IN THE PRE AND POST LAPAROSCOPIC ERAS. DB Nguyen, W Silen, and RA Hodin. Dept of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

3588 FORCE FEEDBACK GRASPER HELPS RESTORE SENSE OF TOUCH IN MINIMALLY INVASIVE SURGERY. M. MacFarlane; J. Rosen*; B. Hannaford*; C. Pellegrini; M. Sinanan. Dept. of Surgery and Electrical Engineering*; University of Washington, Seattle, Washington.

960 PROGNOSTIC VALUE OF FAS RECEPTOR AND RB PROTEIN EXPRESSION IN PATIENTS WITH ESOPHAGEAL ADENO-CARCINOMA ARISING IN BARRETT'S METAPLASIA. Domenico Coppola; Linda Mora; Robert Schreiber; William Dalton; and Richard C. Karl.

961 CLINICAL AND FUNCTIONAL RESULTS OF PRIMARY LAPAROSCOPIC MYOTOMY AND ANTERIOR FUNDOPLICATION FOR ESOPHAGEAL ACHALASIA. L.Bonavina, G.Micheletto, M.Pagani, L.Antoniazzi, R.Rosati, A.Segalin, G.Marotta, and A.Peracchia. Department of Surgery, University of Milan School of Medicine, Milan, Italy.

962 MINIMALLY INVASIVE SURGERY FOR DIFFUSE ESOPHAGEAL SPASM AND NUTCRACKER ESOPHAGUS. D. Tyrrell, M.G. Patti, M. Arcerito, C. Feo, J. Tong, W. Gantert, and L.W. Way, Department of Surgery, University of California, San Francisco. San Francisco, CA.

963 BILE SALT-INDUCED MUTATION IN VITRO. J. Theisen, J.H. Peters, M. Hughes, N. Baril, K. Skinner, C.G. Bremner, G.M.R. Campos, O.L. Gastal, M. Hashemi, D. Nhera, T.R. DeMeester, P.W. Laird Department of Surgery, University of Southern California, Los Angeles, California.

964 RESPIRATORY AND PHARYNGEAL SYMPTOMS: A COMMON MANIFESTATION IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE. Kauer WKH, Balint A, Stein HJ, Feu_ner H, Siewert JR Department of Surgery, Technical University, Munich, Germany.

965 THE P21 CYCLIN-DEPENDENT KINASE PROTECTS ESOPHAGEAL CARCINOMA CELLS FROM RADIATION. D.A. Rigberg, F.S. Kim, T.A. Blinman, J. So, D.W. McFadden, Dept of Surgery, UCLA, Los Angeles, CA.

966 IMMUNOHISTOCHEMICAL ASSESSMENT OF 17-1A AND COMPLEMENT RESISTANCE FACTORS CD55 AND CD59 IN ESOPHAGEAL CANCER. S.B. Hosch, S. Inndorf, S. Bull, F. Stern, K. Pantel, J.R. Izbicki. Departments of Surgery, University of Hamburg, and Immunology, University of Munich, Germany.

967 VIDEOSURGERY ESOPHAGECTOMY. HW Pinotti, CE Domene, MA Santo, P Volpe, P Onari, F Atui - Digestive Surgery Department. University of São Paulo Medical School, Sao Paulo, Brazil.

968 INTRATRACHEAL LONG-TERM PH MONITORING: A NEW METHOD TO EVALUATE EPISODES OF SILENT ASPIRATION IN PATIENTS AFTER ESOPHAGECTOMY AND GASTRIC PULL UP. Kauer WKH, Stein HJ, Bartels HJ, Siewert JR Department of Surgery, Technical University Munich, Germany.

969 SURGERY OF GASTRODUODENAL ULCER: EVOLUTION OF SURGICAL RECRUITMENT (1972-1996). O Huber, JM Megevand, R Chautems, P Majno, Ph Morel. Department of Surgery. University Hospital of Geneva. Geneva. Switzerland.

970 FUNCTIONAL AND SYMPTOMATIC IMPROVEMENT IN PATIENTS WITH DIABETIC GASTROPARESIS FOLLOWING PYLOROPLASTY. Ziad E. Abouezzi, W. Scott Melvin, E. Christopher Ellison, William J. Schirmer. Department of Surgery, The Ohio State University, Columbus, Ohio.

971 SURVIVAL OF GASTRIC CANCER PATIENTS IS DETERMINED BY THE PRESENCE OF LYMPHANGITIS CARCINOMATOSIS. G.P. Schwab, A. Klingler, G. Wetscher, M. Gadenståtter, H.G. Schwelberger, A. Kreczy, R. Pointner. Dpts. of Surgery & Pathology, University of Innsbruck, Dpt of Surgery, Hospital of Zell/See, Austria, Europe.

972 BODY COMPOSITION ASSESSMENT IN PATIENTS FOLLOWING GASTRIC BYPASS SURGERY FOR MORBID OBESITY. J.L. Sebastian. I. Yip, M. Flechtner-Mars, S. Uikema D. Heber and E.H. Livingston. Department of Surgery and Center for Human Nutrition, University of California, Los Angeles, School of Medicine, CA.

973 ROUX-EN-Y GASTRIC BY-PASS (RGBP) AFTER PREVIOUS UNSUCCESSFUL GASTRIC BARIATRIC SURGERY: EARLY RESULTS. A. Westling, M. Ljungdahl, S. Gustavsson. Dept of Surgery, University Hospital, Uppsala, Sweden.

974 CLINICAL OUTCOME AND QUALITY OF LIFE AFTER GASTRIC AND DISTAL ESOPHAGUS REPLACEMENT WITH AN ILEOCOLON INTERPOSITION. J.Metzger1), M. von Flüe2), L. Degen3), Ch. Beglinger3) and F. Harder1). 1)Department of Surgery and 3)Department of Gastroenterology, University Hospital. Basel. Switzerland. 2)Department of Surgery, Canton Hospital. Luzern. Switzerland.

975 DIFFERING EFFECTS OF A CALCITONIN GENE RELATED PEPTIDE (CGRP) RECEPTOR ANTAGONIST (RA) AND AN _-CGRP ANTIBODY (AB) ON POSTOP ILEUS. Mark E. Freeman, Guozhang Cheng, and Michael P. Hocking Department of Surgery, University of Florida, Gainesville, Florida.

P976 2793 ASSESSMENT OF COLONIC PERFUSION DURING COLONIC RESECTION USING SCANNING LASER DOPPLER FLOWMETRY. NH Boyle, WJ Owen, AC Pearce and RC Mason. UMDS, Guy's and St. Thomas' Hospitals, London, UK.

977 BASIC ELECTRICAL RHYTHM (BER) ACTIVITY AS A MEASURE OF BOWEL VIABILITY DURING MESENTERIC ISCHEMIA AND REPERFUSION. JK Ladipo*, SA Seidel*, LA Bradshaw*#, S Halter_, WO Richards*_. Depts. of Surgery* and Physics & Astronomy#, Vanderbilt University, and Depts. of Pathology_ and Surgery_, Veterans Administration Medical Center, Nashville, Tennessee.

978 ENDOTHELIN ANTAGONISM REDUCES THE SYSTEMIC INFLAMMA-TORY RESPONSE IN A MURINE MODEL OF INTESTINAL ISCHEMIA/ REPERFUSION. J.S. Lane, K.E. Todd, D.A. Rigberg, B. Gloor MD, A.D. Kau, S.W. Ashley*, D.W. McFadden, H.A. Reber, C.F. Chandler, Departments of Surgery, UCLA School of Medicine, Los Angeles CA, *Brigham and Women's Hospital, Boston MA.

979 N-ACETYLCYSTEINE ABROGATES THE SYSTEMIC RESPONSE TO MURINE INTESTINAL ISCHEMIA/REPERFUSION. D.A. Rigberg, T.A. Blinman, J.S. Lane, F.S. Kim, O.J. Hines, D.W. McFadden, C.F. Chandler, Division of General Surgery, UCLA, Los Angeles, California.

980 INTESTINAL TRANSPLANTS SHOW IMPAIRED REGULATION OF TRANSIT IN SHORT GUT SYNDROME. C.P. Johnson, S.K. Sarna, Y.R. Zhu, G. Telford, A.M. Roza, M.B. Adams, Departments of Transplant Surgery and General Surgery. Milwaukee, Wisconsin.

981 SMALL BOWEL TRANSPLANTATION (SBT) ALTERS NON-ADRENERGIC NON-CHOLINERGIC (NANC) INHIBITION IN LONGITUDINAL SMOOTH MUSCLE OF THE RAT JEJUNUM. B.M. Balsiger, N. Ohtani, C. Shibata, M.M. Murr, W.J. Anding, J.A. Duenes, M.G. Sarr. Dept. of Surgery, Mayo Clinic, Rochester, MN.

982 ILEAL ABSORPTIVE ADAPTATION TO JEJUNAL RESECTION AND EXTRINSIC DENERVATION: IMPLICATIONS FOR LIVING RELATED SMALL BOWEL TRANSPLANTATION. GG Tsiotos, K Bierens, J Duenes, MG Sarr. Dept. of Surg., Mayo Clinic, Rochester, MN.

983 THE DIFFERENTIAL EFFECT OF HEPATOCYTE GROWTH FACTOR ON INTESTINAL ADAPTATION DEPENDS ON THE TIMING OF EXPOSURE. Y. Kato, K. Alavi, D. Yu, and M.Z. Schwartz. duPont Hospital for Children, Wilmington, DE and Thomas Jefferson University, Philadelphia, PA.

984 DIFFERENTIAL EXPRESSION OF LUMINAL NA+/H+ EXCHANGER ISOFORMS IN THE ILEUM FOLLOWING MASSIVE INTESTINAL RESECTION. CE Shin, M Soleimani*, H Amlal*, RA Falcone Jr, BW Warner. Division of Pediatric Surgery, Children's Hospital Medical Center and * Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati OH.

985 INTESTINAL CELL DIFFERENTIATION IS ASSOCIATED WITH DECREASES IN STAT PROTEINS. S. Wang, B.M. Evers, Dept. of Surgery, Univ. of Texas Medical Branch, Galveston, Texas.

986 ABDOMINAL SURGERY RESULTS IN EARLY STAT PROTEIN ACTIVATION WITHIN THE RAT INTESTINAL MUSCULARIS. J.C. Kalff, C. Hierholzer, W.H. Schraut, T.R. Billiar, D.J. Tweardy and A.J. Bauer. Departments of Surgery and Medicine, University of Pittsburgh, Pittsburgh, PA.

987 EFFECTS OF BURN AND STARVATION ON SMALL BOWEL MUCOSAL APOPTOSIS IN RATS. M DebRoy, SE Wolf, H Ikeda, S Matin, S Rajaraman, DN Herndon and JC Thompson; Shriners Burns Institute, Galveston, Texas.

988 THE CONTINENT ILEOSTOMY: LONG-TERM DURABILITY AND PATIENT SATISFACTION. Virginia R. Litle, Susan Barbour, Theodore R. Schrock and Mark L. Welton University of California, San Francisco, San Francisco, California.

989 THE ROLE OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-_1) IN PERITONITIS-INDUCED ADHESIONS. A. M. Ghellai, N. Chegini, Q. Dou1, J.M. Kaseta2, J.W. Burns2, K.C. Skinner2, A. F. Stucchi and J.M. Becker, Department of Surgery, Boston University School of Medicine, Boston, MA; 2Genzyme Corporation, Cambridge, MA and 1Institute for Wound Research, University of Florida, Gainesville

990 THE SODIUM TRANSPORT-DEPENDENT ABSORPTIVE RESPONSE OF COLONIC EPITHELIUM TO PEPTIDE YY IS DECREASED IN AQUAPORIN-4 KNOCKOUT MICE. K.S. Wang, T. Ma, A.R. Komar, I Cross, A.S. Verkman, J. A. Bastidas. Department of Surgery, Stanford Univ. Sch of Med., Stanford, CA; CVRI, UCSF, San Francisco, C

991 EFFECT OF NEOSTIGMINE ON POSTOPERATIVE COLONIC MOTILITY. COMBINED MANOMETRY/BAROSTAT RECORDINGS. M. E. Kreis, A. Huge, T. T. Zittel, M. Kasparek, G. Thiers, M. J. Starlinger, H. D. Becker, E. C. Jehle. Univ. Hospital, Dep. of Surgery, Tübingen, FRG.

992 COMPARISON OF MEASUREMENT METHODS CALCULATING RECOVERY OF GASTROINTESTINAL MOTILITY FOLLOWING SURGERY. M. Ishikawa, M. Hotokezaka, M.C. Blair, B.D. Schirmer. Department of Surgery, University of Virginia Health Sciences Center, Charlottesville, VA.

993 OGILVIE'S SYNDROME IN THE SURGICAL PATIENT: A NEW THERAPEUTIC MODALITY. C.R. Schermer, J.J. Hanosh, M.Davis, D.E. Pitcher University of New Mexico, Health Sciences Center Albuquerque, NM.

994 CLINICAL SUBTYPES OF CROHN'S DISEASE ACCORDING TO SURGICAL OUTCOME. S. E. Greenway, M. A. Buckmire, R. H. Rolandelli: Allegheny University of the Health Sciences, Philadelphia, PA.

995 STRICTUREPLASTIES FOR COLONIC STENOSIS IN CROHN'S DISEASE. Yuji Funayama, Iwao Sasaki, Hiroo Naito, Kohei Fukushima, Chikasi Shibata, Tuyoshi Masuko, Kein-ichi Takahashi, Hitoshi Ogawa, Shun Sato, Tatsuya Ueno, Akihiko Hashimoto, and Seiki Matsuno. The First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.

996 RENAL TRANSPLANT PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE ARE AT INCREASED RISK FOR COMPLICATED DIVERTICULAR DISEASE OF THE COLON. NN Armstrong, AM D'Alessandro, JS Odorico, M Kalayoglu, HW Sollinger, SJ Knechtle. University of Wisconsin Hospital and Clinics, Madison, WI.

997 DESMOID TUMOURS IN FAMILIAL ADENOMATOUS POLYPOSIS (FAP). C. Soravia, T. Berk, R.S. McLeod, Z. Cohen, Department of Surgery, Familial Gastrointestinal Cancer Registry, Mount Sinai Hospital, University of Toronto, Toronto, Canada.

998 ATTENUATED FAMILIAL ADENOMATOUS POLYPOSIS: ASSOCIATION OF AGE AND POLYP CHARACTERISTICS WITH COLORECTAL CANCER,. D.R. Adams, C.A. Ternent, K.M. Lin, P. Watson, A.G. Thorson, G.J. Blatchford, M.A. Christensen, H.T. Lynch, Departments of Surgery and Preventive Medicine, Creighton University School of Medicine, Omaha, NE.

999 RESULTS OF A 3-YEAR SURVEILLANCE PROGRAM OF MEMBERS OF FAMILIES WITH HEREDITARY NON-POLYPOSIS COLORECTAL CANCER. GB Rossi, M de Bellis, P Marone, PF Maione, L. Panariello*, F Petrulio, A Tempesta and P.Izzo* Endoscopy Unit, National Cancer Institute of Naples; *Department of Molecular Biology, School of Medicine, I University of Naples, Italy.

1000 CEA IS USEFUL TO DETERMINE THE NEED FOR A PREOPERATIVE CT SCAN IN PATIENTS WITH COLORECTAL CANCER. S Kelly, MA Malangoni, Case Western Reserve University, Dept. of Surgery, MetroHealth Medical Center, Cleveland, Ohio.

1001 SUPPRESSION OF ENDONUCLEASE EXPRESSION BY NONSTER-OIDAL ANTIINFLAMMATORY DRUGS (NSAID'S) IN SPORADIC COLORECTAL CANCER. M. S. Kahlenberg, C. Volpe, D. L. Stoler, N. J. Petrelli, and G.R. Anderson. Division of Surgical Oncology and Dep't of Cellular and Molecular Biology, Roswell Park Cancer Institute, State University of NY, Buffalo, NY.

1002 IN VITRO GROWTH OF COLON TUMORS PREDICTS POORER LONG-TERM SURVIVAL. TM Farrell, OS Pettengill, DS Longnecker, K Sullivan, KH Cohn. Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

1003 LAPAROSCOPIC TOTAL MESORECTAL EXCISION AND AUTONOMIC NERVE PRESERVATION IN A CADAVER MODEL. BL Jerby, H Kessler, PW Marcello, T Gramlich, JW Milsom. Departments of Colorectal Surgery and Pathology. The Cleveland Clinic Foundation. Cleveland, OH.

1004 RECTAL CANCER: THE IMPACT OF HIGH DOSE PREOPERATIVE IRRADIATION ON DISTAL SURGICAL MARGINS. J. Marks, J. Cotter, G. Marks, M. Mohiuddin,* Dept. of Surgery, Allegheny University Hospital, Philadelphia, PA; *Dept. of Radiation Medicine, University of Kentucky, Lexington, KY.

1005 PREOPERATIVE CHEMORADIOTHERAPY PERMITS <1 CM DISTAL MARGIN AND SPHINCTER PRESERVATION FOR DISTAL RECTAL CANCER. B.W. Kuvshinoff. I. Magfoor. B. Miedema. J. Wilkes. S. Westgate, and D.M. Ota. Dept. of Surgery, University of Missouri Ellis Fischel Cancer Center and Harry S. Truman VAMC, Columbia, Missouri.

1006 THE ROLE OF LAPAROSCOPY IN THE TREATMENT OF MID AND LOW RECTAL CANCER LESIONS. IS IT SAFE AND FEASIBLE? M.E. Franklin, D. Abrego, J.E. Balli, J.P. Dorman, J.L. Glass, H. Martinez, C. Peña. Texas Endosurgery Institute, San Antonio, Texas.

1007 FASCIAL CLOSURE DECREASES PORT SITE IMPLANTATION FOLLOWING LAPAROSCOPY IN A RAT PERITONEAL SEEDING MODEL. A.B. Johnson, D. Dillehay, K. Macken, G.W. Daneker, and J.G. Hunter. Department of Surgery, Emory University School of Medicine. Atlanta, GA.

1008 CONTINENCE FUNCTION IN PATIENTS WITH RECTAL PROLAPSE: PRE- AND POSTOPERATIVE MANOMETRIC FINDINGS. S.M.Muehldorfer, K.E. Matzel*, U. Stadelmaier*, Th. Schneider, E.G. Hahn. Depts. of Medicine and Surgery*, University of Erlangen-Nuremberg, Germany.

1009 A PUDENDAL NERVE INNERVATED SARTORIUS NEOANAL SPHINCTER. A CANINE MODEL. Denis CNK Nyam, Department of Colorectal Surgery, Singapore General Hospital.

1010 TOWARDS A BETTER DEFINITION OF HEMANGIOMAS OF THE RECTUM. JM Sarmiento, S. Nivatvongs, S. Zaheer. Mayo Clinic, Rochester, MN.

1011 CARBOXYPEPTIDASE A ACTIVITY IN PANCREATIC CANCER AND ACUTE PANCREATITIS. P. Shamamian*, S. Marcus*, E. Deutsch*, T. Maldonado*, A. Liu_, J. Stewart_, K. Eng*, C. Gilvarg_. *Department of Surgery, NYU School of Medicine, NY, NY; _Department of Molecular Biology, Princeton University, Princeton, NJ.

1012 AGM-1470 REDUCES VASCULARIZATION OF THE DUCTAL PANCREATIC CARCINOMA. INTRAVITAL MICROSCOPIC OBSERVATIONS IN THE DORSAL SKIN-FOLD CHAMBER OF THE RAT: A NOVEL MODEL FOR EVALUATING ANTI-ANGIOGENETIC THERAPY. H.G. Hotz, Th. Foitzik, B. Hotz, G. Eibl, A. Menrath*, H.A. Reber°, H.J. Buhr. Depts. of Surgery, B. Franklin Medical Center, Freie Univ. Berlin, Germany and °UCLA School of Medicine, Los Angeles, CA, and *Schering AG, Berlin, Germany.

1013 SEVERE HYPERSTIMULATION/OBSTRUCTION PANCREATITIS: A MODEL CHARACTERIZED BY ACINAR ATROPHY AND INTERSTITIAL PANCREATIC FIBROSIS. K. Murayama*, B. Barent+, A. Brooks+, M. Gruber+, S. Eliason@, E. Brunt@, G. Smith*. Depts of *Surgery and @Pathology, St. Louis University, St. Louis, MO and +Dept of Surgery, University of Nebraska Medical Center, Omaha, NE.

1014 INFLUENCE OF CONTRAST MEDIUM AND OCTREOTIDE ON THE DEVELOPMENT OF PANCREATIC NECROSIS. W.Uhl, M.W.Büchler and the German Pancreatitis Study Group, Department of Visceral and Transplantation Surgery, University Hospital of Bern, CH 3010 Bern, Switzerland.

1015 MATRIX METALLOPROTEINASE (MMP) 2 AND 9 ACTIVITY IN EXPERIMENTAL ACUTE PANCREATITIS. S. Patel, J. Schwartz, N. Chaung, S. G. Marcus, H. L. Pachter, E. Deutsch, A. C. Galloway, K. Eng, P. Mignatti, P. Shamamian. S. Arthur Localio Laboratory, Department of Surgery, NYU Medical Center, NY, NY.

1016 ACUTE PANCREATITIS FOLLOWING CARDIAC TRANSPLANT-ATION IS SIGNIFICANTLY INCREASED COMPARED WITH OTHER CARDIAC PROCEDURES. AJ Herline, J Debelak, CW Pinson, D Harley, W Merrill, T Starkey, R Pierson, WC Chapman. Departments of Surgery and Cardiothoracic Surgery, Vanderbilt University Medical Center and St. Thomas Hospital, Nashville, TN.

1017 REGULATION OF PANCREATIC DUCT CELL GROWTH BY TRANSFORMING GROWTH FACTOR BETA (TGF_) IN VITRO. C. Alvarez, B.L. Bass. University of Maryland and Surgical Service, Baltimore VAMC, Baltimore, MD 21201.

1018 APOPTOSIS INHIBITION DETERIORATES THE PROGNOSIS IN PANCREATIC CANCER. H. Friess, Z. Lu1, A. Andren-Sandberg, A. Zimmermann*, G. Adler**, R. Schmid**, M.W. Büchler; Department of Visceral and Transplantation Surgery and *Institute of Pathology, University of Bern, Switzerland; **Dept of Gastroenterology, University of Ulm, Germany.

1019 MAGNETIC RESONANCE IMAGING (MRI) WITH MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY (MRCP) PREDICTS RESECTABILITY AND DUCTAL ABNORMALITIES IN BENIGN AND MALIGNANT PANCREATIC DISEASE. S.N. Hochwald, M. Dobryansky, N. Rofsky, P. Shamamian, S.G. Marcus New York University Medical Center, New York, New York.

1020 THE ROLE OF POSITRON EMISSION TOMOGRAPHY (PET SCAN) IN THE DIAGNOSIS AND STAGING OF PANCREATIC CANCER. Lisa Clark*, R. Anthony Perez-Tamayo, Herb Hurwitz, Stan Branch, John Baillie, Paul Jowell, Edward Coleman, Theodore Pappas, Mary Keogan, and Douglas Tyler. Duke University Medical Center, Durham, North Carolina.

1021 INTRAOPERATIVE ULTRASOUND IMPROVES DIAGNOSTIC AND THERAPEUTIC STRATEGIES DURING PANCREATIC SURGERY. R.J. Hendrickson, C.M. Schmidt, C.R. Cappadona, L.T. Tio* and J.V. Sitzmann. Departments of Surgery and *Medicine, Georgetown University Medical Center. Washington, DC.

1022 REEXPLORATION FOR PERIAMPULLARY CARCINOMA: RESECTABILITY, PERIOPERATIVE RESULTS, PATHOLOGY AND LONG-TERM OUTCOME. T A Sohn, KD Lillemoe, JL Cameron, H A Pitt, J Huang, RH Hruban, CJ Yeo. Dept of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD.

1023 PRESUMED MALIGNANT BILIARY OBSTRUCTION DESPITE A NORMAL CT: DATA TO SUPPORT PANCREATICO-DUODENECTOMY (PD). M Bouvet, R Bold, J Lee, P Pisters, J Abbruzzese, I Raijman, C Charnsangavej, DB Evans. The University of Texas M. D. Anderson Cancer Center, Houston, TX

1024 DELAYED GASTRIC EMPTYING OCCURS AFTER BOTH CLASSICAL AND PYLORUS-PRESERVING WHIPPLE PROCEDURE. A Andrén-Sandberg, M Wagner, HU Baer, W Uhl, H Friess and MW Büchler. Department of Visceral and Transplantation Surgery, University Hospital of Bern, Switzerland.

1025 QUALITY OF LIFE DURING THE FIRST YEAR AFTER PPPD FOR PERIAMPULLARY CARCINOMA. E.J.Nieveen van Dijkum1, C.B. Terwee2, J.H.vd Meulen2, H.C. de Haes3, J.J.B. van Lanschot1, D.J. Gouma1. Depts of Surgery, Epidemiology2 and Medical Psychology3, Academic Medical Center, Amsterdam, The Netherlands.

1026 THE IMPACT OF SPLENECTOMY ON OUTCOME AFTER RESECTION OF PANCREATIC ADENOCARCINOMA. R.E. Schwarz, L.E. Harrison, D.S. Klimstra, M.F. Brennan City of Hope National Medical Center, Duarte, CA, and Memorial Sloan-Kettering Cancer Center, New York, NY.

1027 THE EFFECT OF AN EICOSAPENTAENOIC ACID-ENRICHED NUTRITIONAL SUPPLEMENT IN WEIGHT-LOSING PATIENTS WITH ADVANCED PANCREATIC CANCER. M.D. Barber, J.A. Ross, K.C.H. Fearon, A.C. Voss Royal Infirmary, Edinburgh, Scotland, UK.

1028 CANCER OF THE PAPILLA (AMPULLA) OF VATER: CLINICO-PATHOLOGICAL AND MOLECULAR FACTORS INFLUENCING SURVIVAL AND TREATMENT. C Iacono1, A Scarpa2, G Zamboni2, G Verlato3, L Bortolasi1, A Baron2, G Serio1. Departments of Surgery1, Pathology2, and Medical Statistics3, University of Verona, ITALY.

1029 THE ROLE OF INTRAOPERATIVE INSULIN MONITORING IN SURGICAL MANAGEMENT OF INSULINOMA. K. Amikura, R. Nakamura, K. Arai, M. Kobari, S. Matsuno. The First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.

1030 TREATMENT WITH ANTI-INTERLEUKIN-12 MONOCLONAL ANTIBODY ALLEVIATES ACUTE REJECTION OF MOUSE ISLET ALLOGRAFTS. Y.Wada, K.Arai, M. Sunamura, M.Kobari, and S.Matsuno. First Dept of Surgery, Tohoku University School of Medicine, Sendai, Japan.

1031 GENERATION OF A TISSUE SPECIFIC TRANSGENIC MOUSE MODEL USING CRE RECOMBINASE LINKED TO AN INSULIN PROMOTER. M.K. Ray, F.J. DeMayo, F.C. Brunicardi. Departments of Surgery and Cell Biology, Baylor College of Medicine, Houston, TX.

1032 ANTITHROMBIN III REDUCES LEUKOCYTE-ENDOTHELIAL INTER-ACTION AFTER WARM HEPATIC ISCHEMIA IN RATS. Sasa-Marcel Maksan, Martha Maria Gebhard_, Marc-Oliver Maksan*, Christian Herfarth, Ernst Klar. Departments of Surgery and Experimental Surgery_, University of Heidelberg, Department of Neurosurgery*, University of Bonn, Germany.

1033 ARTERIAL EMBOLISATION SIGNIFICANTLY IMPROVES THE HYPERTHERMIC EFFECT OF LASER-INDUCED THERMO-THERAPY IN LIVER METASTASIS IN RATS. D. Albrecht, C. Germer, C. Isbert, A. Roggan, HP. Ritz, D. Schuppan and H.J. Buhr. Department of Surgery, Medical Center Benjamin Franklin, Freie Universität Berlin, Germany.

1034 PRECONDITIONING PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY OF THE LIVER. B. Nilsson, B. Gustafsson, S. Friman, D. Delbro. Department of Surgery, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden.

1035 DEFINITIVE TREATMENT OF GIANT HEPATIC HEMANGIOMAS: ENUCLEATION VERSUS RESECTION. JF Buell, LB Johnson, PC Kuo, JS Plotkin, R Gedaly-Eidelman, WD Lewis, RL Jenkins. University of Maryland, School of Medicine, Baltimore, Maryland, Beth Israel-New England Deaconess, Harvard Medical School, Boston, Massachusetts.

1036 DO HEPATIC RESECTIONS NEED TO BE PERFORMED AT HIGH-VOLUME REFERRAL CENTERS? William P. Reed, M.D.,Beth A. Halla, R.N., Jane L. Garb, Baystate Medical Center, Springfield, MA.

1037 PROGNOSTIC FACTORS AFTER HEPATECTOMY FOR HEPATO-CELLULAR CARCINOMA. H. Lau, S.T. Fan, I. Ng1, J. Wong. Departments of Surgery and Pathology1, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

1038 EFFECT OF AN INITIAL POSITIVE MARGIN ON THE PROGNOSIS OF PATIENTS UNDERGOING LIVER RESECTION FOR HEPATOCELLULAR CARCINOMA. G.R. Huffman, A. Uzar, M.A. Choti. Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD.

1039 LIVER RESECTION FOR NONCOLORECTAL NONNEURO-ENDOCRINE HEPATIC METASTASES. T. D.Sielaff, B. Langer, T. Van der Meer, B.R. Taylor, P.D. Greig, S. Gallinger, A.W. Hemming. Department of Surgery, University of Toronto. Toronto, Ontario, Canada.

1040 APPLICATION OF LIVING-RELATED AND SPLIT-LIVER TRANSPLANTA-TION TO ADULTS: AN ANATOMIC STUDY. P.R. Reichert, J.F. Renz, R.C. Lim, J.P. Roberts, and N.L. Ascher, University of California, San Francisco, CA.

1041 BILIARY CYSTADENOMA: AN ONGOING DIAGNOSTIC CHALLENGE. T.J. VanderMeer, T.D. Sielaff, A. Blumenfeld, B.R. Taylor, and B. Langer. The Toronto Hospital and the University of Toronto. Toronto, CANADA.

1042 EFFECTIVE TOXIN GENE EXPRESSION VIA ADENOVIRAL INFECTION OF HUMAN CHOLANGIOCARCINOMA CELLS IN THE PRESENCE OF HUMAN BILE. L.C. Pederson, D.J. Buchsbaum, M.A. Stackhouse, D.T. Curiel and S.M. Vickers, Departments of Surgery, Radiation Oncology, and Gene Therapy, University of Alabama at Birmingham. Birmingham AL.

1043 IL-1_ STIMULATES MUCUS SECRETION IN GALLBLADDER EPITHELIAL CELLS. C.H. Cheung, J.B. Prystowsky, E.W. Moore, R.V.Rege, Northwestern University Medical School. Chicago, IL and Medical College of Virginia, Richmond, VA.

1044 ANION EXCHANGER AE-2 MEDIATES CHLORIDE TRANSPORT BY GALLBLADDER EPITHELIUM. A. J. Moser, K. Graf, Z. R. Abedin, K. E. Morgenstern, P. R. Smith, J.J. Roslyn, M. Z. Abedin. Dept. of Surgery, Allegheny University of the Health Sciences, and Research Services, Phila VAMC, Philadelphia, PA.

1045 IRON DEFICIENCY INHIBITS GALLBLADDER MOTILITY. K.P.Murray, J.H. Shin, M.K.Fox-Talbot, S.M. Johnston, P.A.Lipsett, K.D. Lillemoe and H.A.Pitt. Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD and Medical College of Wisconsin, Milwaukee, WI.

1046 MANAGEMENT OF DUODENAL PERFORATION AFTER ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY. M. V. Stapfer, R. Yang, N. Jabour, S. C. Stain, R. Selby, and D. Garry, University of Southern California, Los Angeles, CA.

1047 ERCP-ASSOCIATED DUODENAL PERFORATION USUALLY CAN BE TREATED NON-OPERATIVELY. R.B. Claytor#, F.J. Vittimberga#, M. Malik#, J. Saltzman+, P. Krims+, M.P. Callery#, R.S. Swanson#. Departments of Surgery (#) and Medicine (+), University of Massachusetts Medical Center. Worcester, Massachusetts.

1048 INTRA-OPERATIVE BILIARY MANOMETRY IN THE EVALUATION OF CHRONIC ACALCULOUS CHOLECYSTITIS. Scott W. Lucas and Maurice E. Arregui, St. Vincent Hospital and Health Center. Indianapolis, IN.

1049 WHAT MAKES FOR A SATISFIED PATIENT THREE MONTHS AFTER CHOLECYSTECTOMY? AN OUTCOME ANALYSIS OF 1325 PATIENTS. L. W. Traverso, R. Lonborg, L. F. Fenster, Virginia Mason Clinic, Seattle, WA.

1050 MINI-LAPAROSCOPIC CHOLECYSTECTOMY: EVALUATING A NEW APPROACH. PR Reardon, JI Kamelgard, BA Applebaum, FC Brunicardi. Baylor College of Medicine, Houston, Texas.

1051 PREOPERATIVE ERCP IS MORE COSTLY THAN INTRAOPERATIVE OR POSTOPERATIVE ENDOSCOPIC AND SURGICAL TECHNIQUES IN THE MANAGEMENT OF CHOLEDOCHOLITHIASIS. JW Hazey, LM Rock, JM Marks, D Asseff, JL Ponsky, Department of Surgery, Case Western Reserve University, Cleveland, OH.

1052 CHOLANGIOGRAPHY DURING LAPAROSCOPIC CHOLECYST-ECTOMY: CUMULATIVE SUM ANALYSIS OF AN INSTITUTIONAL LEARNING CURVE. M. Molloy, S.B. Archer, P.O. Hasselgren, B.J. Dalton, and R.H. Bower, Surgical Service, VA Medical Center, Cincinnati, OH.

1053 DECLINING RATE OF COMMON BILE DUCT OPERATIONS: A STATE-WIDE, FIVE-YEAR TIME-SERIES ANALYSIS. T Huynh, R. Rutledge, J.S. Guy and C.C. Baker. Department of Surgery, University of North Carolina, Chapel Hill, North Carolina.

1054 S4B+S5 RESECTION WITH TOTAL CAUDATE LOBECTOMY USING TAJ MAHAL LIVER INCISION FOR CARCINOMA OF THE BILIARY TRACT. Y.Kawarada, M.Tabata, K.Yamagiwa, H.Taoka, S.Isaji, H.Yokoi, Y. Ogura and T.Noguchi. First Dept. of Surg., Mie Univ School of Medicine, Japan.

1055 C3A, ENDOTOXIN AND ENDOTOXIN-NEUTROLIZING CAPACITY AS PREDICTORS OF SURVIVAL IN PERITONITIS. T. Brückner, R Urbaschek*, E Klar, Ch. Herfarth. Dept. of Surgery, University of Heidelberg, Germany; Dept. of Microbiology*, University of Mannheim, Germany.

1056 THE THORACIC DUCT IS NOT A MAJOR ROUTE OF BACTERIAL TRANSLOCATION IN PATIENTS WITH MULTIPLE ORGAN FAILURE. L.C.J.M. Lemaire,1,2 J.J.B. van Lanschot,1 C.P Stoutenbeek,3 S.J.H. van Deventer,2 J. Dankert,4 D.J. Gouma1. Depts. of Surgery,1 Intensive Care Medicine,3 and Microbiology4 and the Laboratory for Experimental Internal Medicine2, Academic Medical Centre, Amsterdam, The Netherlands.

1057 ARE STAPLED ANASTOMOSES IN GI SURGERY JUSTIFIED? K.A. GAWAD, J.R. IZBICKI, S.B. HOSCH, S. QUIRRENBACH, W.T. KNOEFEL, H.-U. KÜPPER*, C.E. BROELSCH. Department of Surgery, University of Hamburg and Institute of Controlling*, Universitiy of Munich, Germany.

1058 LAPAROSCOPIC BOWEL RESECTION IN CROHN'S PATIENTS OFFERS MANY ADVANTAGES OVER OPEN SURGERY. M.F. Kutka, M.A. Talamini, H. Kaufman, B.K. Poulose, R.C. Moesinger, Department Of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.

1059 INTERVAL APPENDECTOMY IN THE LAPAROSCOPIC ERA. DB Nguyen, W Silen, and RA Hodin, Dept of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

1060 RETROPERITONEAL AND MESENTERIC CYST: CHARACTERISTICS AND SURGICAL MANAGEMENT. B.K. Poulose, M.F. Kutka, M.A. Talamini, K.D. Lillemoe, and J.L. Cameron, The Johns Hopkins University School of Medicine. Baltimore, Maryland.

1061 TPN AFFECTS HUNGER BUT NOT SATIETY IN FEMALE RATS. V. Kotha, M. Varma, Z -J Yang, C. Chen, and M.M.Meguid. Surgical Metabolism & Nutrition Laboratory, Dept Surgery, Syracuse NY 13210.

1062 ABDOMINAL TUBERCULOSIS. Ömer Alabaz, MD, Alper Akinoglu, MD. University of Çukurova, Department of General Surgery, Adana, Turkey.